Ligand gated sodium channel:
Here the channel protein is cylindrical which is normally closed. When a physiological ligand
(molecule e.g. Acetylcholine) binds with the cylindrical protein at specific
position, the channel is opened and sodium ion enters the cell. Here action
potential causes the release of these ligands which bind with the channel to
activate it.
| Fig: Acetylcholine Gated Sodium Channel |
Above is an example of ligand gated
channel regulated by acetylcholine. The protein receptor is pentameric (has
five subunits). It contains two α subunits, one β subunit, one γ subunit and
one δ subunit. All of these five subunits cross the cell membrane and form
walls of a cylinder. This cylinder has the diameter of 8 nm. Normally this
cylinder is closed. But when two acetylcholine molecule bind with the α
subunits (in the extracellular region of course) a conformational change occurs
and the channel is opened for a brief moment. Then Na+ can
enter the cell.
Acetylcholine is released from the
presynaptic neuron or from neuron of neuro-muscular junction and affects the
receptors present in postsynaptic neuron or muscle respectively.
The ligand gated sodium channel is
to some extent permeable to K+.
Once again, my drawing is not very good, so I am sorry if the picture is not understandable.
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